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公开(公告)号：US20140088055A1
公开(公告)日：2014-03-27
申请号：US13936823
申请日：2013-07-08
申请人： Calvin Bruce HARLEY , Soo-Peang KHOR , Mahesh RAMASESHAN , Premchandran H. RAMIYA , Zhu Z. PIROT , Steven FAUCE , Tong LIN
发明人： Calvin Bruce HARLEY , Soo-Peang KHOR , Mahesh RAMASESHAN , Premchandran H. RAMIYA , Zhu Z. PIROT , Steven FAUCE , Tong LIN
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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公开(公告)号：US08481721B2
公开(公告)日：2013-07-09
申请号：US12781515
申请日：2010-05-17
申请人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
发明人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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公开(公告)号：USRE42013E1
公开(公告)日：2010-12-28
申请号：US12636048
申请日：2009-12-11
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0812
摘要： The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
摘要翻译： 本发明提供已被证明是生长素释放肽受体（生长激素促分泌素受体，GHS-R1a和亚型，同种型及其变体）的选择性调节剂的新型构象定义的大环化合物。 本文还描述了合成新化合物的方法。 这些化合物可用作生长素释放肽受体的激动剂，并且用作治疗和预防一系列医学病症的药物，包括但不限于代谢和/或内分泌疾病，胃肠道疾病，心血管疾病，肥胖症和肥胖相关疾病， 中枢神经系统疾病，遗传疾病，过度增殖性疾病和炎症性疾病。
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公开(公告)号：US20090137817A1
公开(公告)日：2009-05-28
申请号：US12197610
申请日：2008-08-25
申请人： Pierre Deslongchamps , Yves Dory , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid R. Hoveyda , Sylvie Beaubien , Mark L. Peterson
发明人： Pierre Deslongchamps , Yves Dory , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid R. Hoveyda , Sylvie Beaubien , Mark L. Peterson
IPC分类号： C07D277/20 , C07D233/66 , C07D263/30
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含有特定构象控制元件的新的空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地，根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：US20050119169A1
公开(公告)日：2005-06-02
申请号：US10911219
申请日：2004-08-02
申请人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
发明人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gerald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark Peterson , Hamid Hoveyda , Sylvie Beaubien , Eric Marsault
IPC分类号： A61K38/12 , C07D491/02 , C07K1/04 , C07K5/00 , C07K5/08
CPC分类号： C07K1/047 , C07K5/0802
摘要： Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了引入肽键代用品的新型空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地，根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：US20100292197A1
公开(公告)日：2010-11-18
申请号：US12781515
申请日：2010-05-17
申请人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
发明人： Calvin B. Harley , Soo-Peang Khor , Mahesh Ramaseshan , Premchandran Ramiya , Zhu Zhen Pirot , Steven Fauce , Tong Lin
IPC分类号： A61K31/58 , C07J53/00 , A61P1/00 , A61P9/00 , A61P17/02 , A61P35/00 , A61P31/18 , A61P25/28 , A61P19/00 , A61P11/00 , C12N5/02
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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7.发明授权Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists 有权构象控制的生物活性大环小分子作为胃动素拮抗剂或生长素释放肽激动剂公开(公告)号：US07452862B2
公开(公告)日：2008-11-18
申请号：US10911221
申请日：2004-08-02
申请人： Pierre Deslongchamps , Yves Dory , Mark Peterson , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vézina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gérald Villeneuve , Hamid Hoveyda , Sylvie Beaubien , Graeme L Fraser
发明人： Pierre Deslongchamps , Yves Dory , Mark Peterson , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vézina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gérald Villeneuve , Hamid Hoveyda , Sylvie Beaubien , Graeme L Fraser
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含有特定构象控制元件的新的空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地，根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：US20060025566A1
公开(公告)日：2006-02-02
申请号：US11149731
申请日：2005-06-10
申请人： Hamid Hoveyda , Mark Peterson , Graeme Fraser , Mahesh Ramaseshan
发明人： Hamid Hoveyda , Mark Peterson , Graeme Fraser , Mahesh Ramaseshan
IPC分类号： C07K5/12
CPC分类号： C07K5/0827 , A61K38/00 , C07D273/00 , C07D498/08 , C07K5/0808 , C07K5/0812
摘要： The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
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公开(公告)号：US20050137127A1
公开(公告)日：2005-06-23
申请号：US10911221
申请日：2004-08-02
申请人： Pierre Deslongchamps , Yves Dory , Mark Peterson , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid Hoveyda , Sylvie Beaubien
发明人： Pierre Deslongchamps , Yves Dory , Mark Peterson , Kamel Benakli , Eric Marsault , Luc Ouellet , Mahesh Ramaseshan , Martin Vezina , Daniel Fortin , Ruoxi Lan , Shigui Li , Gerald Villeneuve , Hamid Hoveyda , Sylvie Beaubien
CPC分类号： C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
摘要翻译： 公开了含有特定构象控制元件的新的空间定义的大环化合物。 然后使用这些大环的文库来选择一种或多种与特定生物目标具有特异性相互作用的大环类物质。 特别地，根据本发明的化合物被公开为哺乳动物胃动素受体和哺乳动物生长素释放肽受体的激动剂或拮抗剂。
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公开(公告)号：US08557765B2
公开(公告)日：2013-10-15
申请号：US12471978
申请日：2009-05-26
申请人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gérald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Éric Marsault , Graeme L. Fraser
发明人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gérald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Éric Marsault , Graeme L. Fraser
IPC分类号： A61P3/04
CPC分类号： C07K1/047 , C07K5/0802
摘要： Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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