发明授权
US08557825B2 Sulfonyl-derivatives as novel inhibitors of histone deacetylase
有权
磺酰基衍生物作为组蛋白脱乙酰酶的新型抑制剂
- 专利标题： Sulfonyl-derivatives as novel inhibitors of histone deacetylase
- 专利标题（中）： 磺酰基衍生物作为组蛋白脱乙酰酶的新型抑制剂
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申请号： US13325330申请日： 2011-12-14
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公开(公告)号： US08557825B2公开(公告)日： 2013-10-15
- 发明人: Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
- 申请人： Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviene Van heusden
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D295/26
摘要：
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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