- 专利标题： Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
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申请号： US12793413申请日： 2010-06-03
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公开(公告)号： US08557983B2公开(公告)日： 2013-10-15
- 发明人: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
- 申请人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
- 申请人地址： US IL North Chicago
- 专利权人： Abbvie Inc.
- 当前专利权人： Abbvie Inc.
- 当前专利权人地址： US IL North Chicago
- 代理机构： Jones Day
- 主分类号： C07D403/14
- IPC分类号： C07D403/14 ; C07D413/14
摘要：
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.