发明授权
- 专利标题： Engineered anti-alpha V-integrin hybrid antibodies
- 专利标题（中）： 工程抗αV整合素杂交抗体
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申请号： US12669408申请日： 2008-07-17
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公开(公告)号： US08562986B2公开(公告)日： 2013-10-22
- 发明人: Simon Goodman , Diane Hahn , Francesc Mitjans , Jaume Adan , Kin-Ming Lo
- 申请人： Simon Goodman , Diane Hahn , Francesc Mitjans , Jaume Adan , Kin-Ming Lo
- 申请人地址： DE Darmstadt
- 专利权人： Merck Patent GmbH
- 当前专利权人： Merck Patent GmbH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Goodwin Procter LLP
- 优先权： EP07013964 20070717
- 国际申请： PCT/EP2008/005852 WO 20080717
- 国际公布： WO2009/010290 WO 20090122
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The invention relates to engineered antibodies which specifically bind to integrin receptors, especially the alpha V integrin receptor subunit. The antibodies comprise the antigen binding sites (CDRs) of a known mouse anti-integrin antibody, as well as hybrid light chain variable sequences, mutated heavy chain variable sequences (Frs) and modified heavy chain constant sequences. The novel antibodies have improved immunogenic and expression properties and elicit excellent anti-angiogenic as well as anti-tumor activities in humans in monotherapy but also and above all in combination with other angiogenesis and tumor inhibiting agents.
公开/授权文献
- US20100254977A1 ENGINEERED ANTI-ALPHA V-INTEGRIN HYBRID ANTIBODIES 公开/授权日：2010-10-07
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