An enhanced general input/output communication architecture, protocol and related methods are presented. In one embodiment, a method for an enhanced general input/output communication architecture includes initializing a flow control mechanism within an general input/output (GIO) interface associated with a virtual channel upon initialization of the virtual channel, and tracking receive buffer availability in a remote GIO interface coupled with the GIO interface by the virtual channel by monitoring an indication associated with an amount of content transmitted from the GIO interface to the remote GIO interface.