An embodiment of a print signal generation system is provided. The system comprises a sensor, a divisor processing unit, a reference signal generator, and a print trigger signal generator. The sensor detects a first offset of a first location of a medium being printed. The divisor processing unit generates a first divisor according to the first offset and a predetermined divisor. The reference signal generator generates a reference signal. The print trigger signal generator generates a print trigger signal according to the first divisor and the reference signal.