发明授权
- 专利标题: Pharmaceutical formulation for the production of rapidly disintegrating tablets
- 专利标题(中): 用于生产快速崩解片的药物制剂
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申请号: US12663036申请日: 2008-06-02
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公开(公告)号: US08568780B2公开(公告)日: 2013-10-29
- 发明人: Karl Kolter , Michael Schönherr , Silke Gebert , Kathrin Meyer-Böhm , Angelika Maschke
- 申请人: Karl Kolter , Michael Schönherr , Silke Gebert , Kathrin Meyer-Böhm , Angelika Maschke
- 申请人地址: DE Ludwigshafen
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: DE Ludwigshafen
- 代理机构: Novak Druce Connolly Bove + Quigg LLP
- 优先权: EP07109717 20070606
- 国际申请: PCT/EP2008/056763 WO 20080602
- 国际公布: WO2008/148731 WO 20081211
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K47/26 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K9/20
摘要:
Pharmaceutical formulation in the form of compacts comprising A) an agglomerated excipient content composed of a1) 60-97% by weight of sugar or sugar alcohols, a2) 1-25% by weight of a disintegrant, selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethylstarch and L-hydroxypropylcellulose, a3) 1-15% by weight of water-insoluble, film-forming polymers a4) 0-15% by weight of water-soluble polymers and a5) 0-15% by weight of further pharmaceutically customary excipients, the total of the components a1) to a5) being 100% by weight, B) at least one active ingredient, C) 0 to 10% by weight, based on the total amount of A) to D), of a lubricant or mold release agent, and D), if appropriate, further pharmaceutical excipients.
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