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    Pharmaceutical formulation for the production of rapidly disintegrating tablets
    2.
    发明授权
    Pharmaceutical formulation for the production of rapidly disintegrating tablets 有权
    用于生产快速崩解片的药物制剂

    公开(公告)号：US08568780B2

    公开(公告)日：2013-10-29

    申请号：US12663036

    申请日：2008-06-02

    申请人： Karl Kolter ,  Michael Schönherr ,  Silke Gebert ,  Kathrin Meyer-Böhm ,  Angelika Maschke

    发明人： Karl Kolter ,  Michael Schönherr ,  Silke Gebert ,  Kathrin Meyer-Böhm ,  Angelika Maschke

    IPC分类号： A61K9/00 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K9/20

    CPC分类号： A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054

    摘要： Pharmaceutical formulation in the form of compacts comprising A) an agglomerated excipient content composed of a1) 60-97% by weight of sugar or sugar alcohols, a2) 1-25% by weight of a disintegrant, selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethylstarch and L-hydroxypropylcellulose, a3) 1-15% by weight of water-insoluble, film-forming polymers a4) 0-15% by weight of water-soluble polymers and a5) 0-15% by weight of further pharmaceutically customary excipients, the total of the components a1) to a5) being 100% by weight, B) at least one active ingredient, C) 0 to 10% by weight, based on the total amount of A) to D), of a lubricant or mold release agent, and D), if appropriate, further pharmaceutical excipients.

    摘要翻译： 压片形式的药物制剂，其包含A）由a1）60-97重量％的糖或糖醇组成的附聚赋形剂含量，a2）1-25重量％的崩解剂，其选自交联聚维酮， 交联羧甲基纤维素，羧甲基淀粉钠和L-羟丙基纤维素，a3）1-15重量％的水不溶性成膜聚合物a4）0-15重量％的水溶性聚合物和a5）0-15重量％ 药用常规赋形剂，组分a1）至a5）的总量为100重量％，B）至少一种活性成分，C）0至10重量％，基于A）至D）的总量 润滑剂或脱模剂，以及D）如果适用，还有药用赋形剂。

    PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF RAPIDLY DISINTERGRATING TABLETS
    7.
    发明申请
    PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF RAPIDLY DISINTERGRATING TABLETS 有权
    用于生产快速消毒片的制药配方

    公开(公告)号：US20100173859A1

    公开(公告)日：2010-07-08

    申请号：US12663036

    申请日：2008-06-02

    申请人： Karl Kolter ,  Michael Schönherr ,  Silke Gebert ,  Kathrin Meyer-Böhm ,  Angelika Maschke

    发明人： Karl Kolter ,  Michael Schönherr ,  Silke Gebert ,  Kathrin Meyer-Böhm ,  Angelika Maschke

    IPC分类号： A61K31/7052 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4402 ,  A61K31/551 ,  A61K31/5513 ,  A61P43/00

    CPC分类号： A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054

    摘要： Pharmaceutical formulation in the form of compacts comprising A) an agglomerated excipient content composed of a1) 60-97% by weight of sugar or sugar alcohols, a2) 1-25% by weight of a disintegrant, selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethylstarch and L-hydroxypropylcellulose, a3) 1-15% by weight of water-insoluble, film-forming polymers a4) 0-15% by weight of water-soluble polymers and a5) 0-15% by weight of further pharmaceutically customary excipients, the total of the components a1) to a5) being 100% by weight, B) at least one active ingredient, C) 0 to 10% by weight, based on the total amount of A) to D), of a lubricant or mold release agent, and D), if appropriate, further pharmaceutical excipients.

    摘要翻译： 压片形式的药物制剂，其包含A）由a1）60-97重量％的糖或糖醇组成的附聚赋形剂含量，a2）1-25重量％的崩解剂，其选自交联聚维酮， 交联羧甲基纤维素，羧甲基淀粉钠和L-羟丙基纤维素，a3）1-15重量％的水不溶性成膜聚合物a4）0-15重量％的水溶性聚合物和a5）0-15重量％ 药用常规赋形剂，组分a1）至a5）的总量为100重量％，B）至少一种活性成分，C）0至10重量％，基于A）至D）的总量 润滑剂或脱模剂，以及D）如果适用，还有药用赋形剂。

    Pharmaceutical Formulation For Producing Rapidly Disintegrating Tablets
    9.
    发明申请
    Pharmaceutical Formulation For Producing Rapidly Disintegrating Tablets 审中-公开
    用于生产快速崩解片的药物制剂

    公开(公告)号：US20120231042A1

    公开(公告)日：2012-09-13

    申请号：US13416558

    申请日：2012-03-09

    申请人： Karl Kolter ,  Silke Gebert ,  Sandra Kruse ,  Michael Schönherr

    发明人： Karl Kolter ,  Silke Gebert ,  Sandra Kruse ,  Michael Schönherr

    IPC分类号： A61K9/00 ,  A61K47/30

    CPC分类号： A61K9/0056 ,  A61K9/2018 ,  A61K9/2027

    摘要： Provided are pharmaceutical formulations in the form of granules comprising a) about 60-96% by weight of non-film-forming sugars or sugar alcohols, b) about 1-10% by weight of film-forming sugars or sugar alcohols, c) about 3-25% by weight of disintegrants, d) about 0-10% by weight of water-insoluble, film-forming polymers e) about 0-15% by weight of further pharmaceutically customary auxiliaries where the sum of components a) to e) is 100% by weight. Also provided are methods of making and using the pharmaceutical formulations described herein.

    摘要翻译： 提供了颗粒形式的药物制剂，其包含a）约60-96重量％的非成膜糖或糖醇，b）约1-10重量％的成膜糖或糖醇，c） 约3-25重量％的崩解剂，d）约0-10重量％的不溶于水的成膜聚合物e）约0-15重量％的其它药学上常规的助剂，其中组分a）至 e）为100重量％。 还提供制备和使用本文所述药物制剂的方法。