Invention Grant
US08569535B2 Substituted benzoylamino-indan-2-carboxylic acids and related compounds
有权
取代的苯甲酰氨基 - 茚满-2-羧酸及相关化合物
- Patent Title: Substituted benzoylamino-indan-2-carboxylic acids and related compounds
- Patent Title (中): 取代的苯甲酰氨基 - 茚满-2-羧酸及相关化合物
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Application No.: US12627546Application Date: 2009-11-30
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Publication No.: US08569535B2Publication Date: 2013-10-29
- Inventor: Thomas Joseph Caulfield , Jennifer Williford Clemens , Robert S. Francis , Brian Scott Freed , Stanly John , Tieu-Binh Le , Brian Pedgrift , Antonio Daniel Ramos , Gerard Charles Rosse , Martin Smrcina , David Squire Thorpe , William Shelly Wire , Jianhong Zhao
- Applicant: Thomas Joseph Caulfield , Jennifer Williford Clemens , Robert S. Francis , Brian Scott Freed , Stanly John , Tieu-Binh Le , Brian Pedgrift , Antonio Daniel Ramos , Gerard Charles Rosse , Martin Smrcina , David Squire Thorpe , William Shelly Wire , Jianhong Zhao
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Ronald G. Ort
- Main IPC: C07C229/00
- IPC: C07C229/00
Abstract:
The present invention relates to novel compounds of the formula Ia: in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity, and are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
Public/Granted literature
- US20100113462A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS Public/Granted day:2010-05-06
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