An optical pickup and an information storage medium system using the same. The optical pickup includes a light source that emits light having a plurality of different wavelengths. The optical pickup includes a diffraction device having a plurality of diffraction patterns corresponding to the plurality of different wavelengths to divide the light incident from the light source unit into main light and sub light. The optical pickup further includes a photo-detector having a first main light reception unit that receives the main light and a first sub light reception unit that receives the sub light so as to detect an information signal and/or an error signal by receiving reflected light. The first sub light reception unit of the photo-detector is shaped so as to reduce reception of noise sub light due to diffraction based on an undesired diffraction pattern of sub light generated the diffraction device.