发明授权
- 专利标题: Fibrous composite for tissue engineering
- 专利标题(中): 组织工程纤维复合材料
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申请号: US10507059申请日: 2003-03-14
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公开(公告)号: US08580291B2公开(公告)日: 2013-11-12
- 发明人: Hoon Choi , I. Wei Chen
- 申请人: Hoon Choi , I. Wei Chen
- 申请人地址: US PA Philadelphia
- 专利权人: The Trustees of the University of Pennsylvania
- 当前专利权人: The Trustees of the University of Pennsylvania
- 当前专利权人地址: US PA Philadelphia
- 代理机构: RatnerPrestia
- 国际申请: PCT/US03/08128 WO 20030314
- 国际公布: WO2005/007802 WO 20050127
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61F2/00
摘要:
Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous/macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds.
公开/授权文献
- US20050226904A1 Fibrous composite for tissue engineering 公开/授权日:2005-10-13