发明授权
- 专利标题： Biodegradable linkers for molecular therapies
- 专利标题（中）： 用于分子疗法的生物可降解接头
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申请号： US13306459申请日： 2011-11-29
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公开(公告)号： US08580545B2公开(公告)日： 2013-11-12
- 发明人: Ivan Alferiev , Robert J. Levy , Ilia Fishbein
- 申请人： Ivan Alferiev , Robert J. Levy , Ilia Fishbein
- 申请人地址： US PA Philadelphia
- 专利权人： The Children's Hospital of Philadelphia
- 当前专利权人： The Children's Hospital of Philadelphia
- 当前专利权人地址： US PA Philadelphia
- 代理机构： RatnerPrestia
- 主分类号： C12N11/06
- IPC分类号： C12N11/06 ; C12N11/00
摘要：
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
公开/授权文献
- US20120141419A1 Biodegradable Linkers for Molecular Therapies 公开/授权日：2012-06-07
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