发明授权
US08586612B2 Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them
有权
哌啶磺酰脲和硫脲,它们的制备,它们的用途和包含它们的药物组合物
- 专利标题: Piperidinesulfonylureas and -thioureas, their preparation, their use and pharmaceutical compositions comprising them
- 专利标题(中): 哌啶磺酰脲和硫脲,它们的制备,它们的用途和包含它们的药物组合物
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申请号: US11761565申请日: 2007-06-12
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公开(公告)号: US08586612B2公开(公告)日: 2013-11-19
- 发明人: Stephanie Hachtel , Heinrich Christian Englert , Uwe Gerlach , Heinz Goegelein , Holger Heitsch , Karl-Heinz Lehr , Stefania Pfeiffer-Marek
- 申请人: Stephanie Hachtel , Heinrich Christian Englert , Uwe Gerlach , Heinz Goegelein , Holger Heitsch , Karl-Heinz Lehr , Stefania Pfeiffer-Marek
- 申请人地址: DE Frankfurt am Main
- 专利权人: Sanofi-Aventis Deutschland GmbH
- 当前专利权人: Sanofi-Aventis Deutschland GmbH
- 当前专利权人地址: DE Frankfurt am Main
- 代理机构: Scully, Scott, Murphy & Presser, P.C.
- 优先权: DE102004061017 20041218
- 主分类号: A61K31/445
- IPC分类号: A61K31/445
摘要:
The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of formula I, in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of formula I are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
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