发明授权
- 专利标题: Nitrogen-containing heterocyclic compound and use of same
- 专利标题(中): 含氮杂环化合物及其用途
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申请号: US13119743申请日: 2009-09-18
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公开(公告)号: US08592454B2公开(公告)日: 2013-11-26
- 发明人: Junya Shirai , Hideyuki Sugiyama , Taku Kamei , Hironobu Maezaki
- 申请人: Junya Shirai , Hideyuki Sugiyama , Taku Kamei , Hironobu Maezaki
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 国际申请: PCT/JP2009/066458 WO 20090918
- 国际公布: WO2010/032856 WO 20100325
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; A61K31/40 ; A61K31/535 ; A61K31/00 ; C07D211/58 ; C07D295/03
摘要:
The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.
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