发明授权
US08597634B2 Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof
有权
由聚乙二醇修饰的干扰素α-2a及其制备方法
- 专利标题: Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof
- 专利标题(中): 由聚乙二醇修饰的干扰素α-2a及其制备方法
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申请号: US12676511申请日: 2007-09-04
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公开(公告)号: US08597634B2公开(公告)日: 2013-12-03
- 发明人: Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
- 申请人: Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
- 申请人地址: CN Fuijan
- 专利权人: Biosteed Gene Expression Tech. Co., Ltd.
- 当前专利权人: Biosteed Gene Expression Tech. Co., Ltd.
- 当前专利权人地址: CN Fuijan
- 代理机构: Jenkins, Wilson, Taylor & Hunt, P.A.
- 国际申请: PCT/CN2007/002643 WO 20070904
- 国际公布: WO2009/030065 WO 20090312
- 主分类号: A61K38/21
- IPC分类号: A61K38/21 ; A61K38/00 ; A61K39/385 ; C07K14/56
摘要:
The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.