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1.发明授权Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof 有权由聚乙二醇改性的干扰素α-2B及其制备方法公开(公告)号：US08597635B2
公开(公告)日：2013-12-03
申请号：US12676525
申请日：2007-09-04
申请人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
发明人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
IPC分类号： A61K38/21 , A61K38/00 , A61K39/385 , C07K14/56
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
摘要： The present invention relates to interferon-α2b modified with Y-shaped branched polyethylene glycol (PEG) at a single Lys residue and the preparation thereof. The peglated IFN-α2b can be used for the preparation of a medicament for treating a disease, e.g. viral infections such as Hepatitis C.
摘要翻译： 本发明涉及在单个Lys残基处用Y型支化聚乙二醇（PEG）修饰的干扰素-α2b及其制备。 聚乙二醇化IFN-α2b可用于制备用于治疗疾病的药物，例如， 病毒感染如丙型肝炎
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2.发明授权Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof 有权由聚乙二醇修饰的干扰素α-2a及其制备方法公开(公告)号：US08597634B2
公开(公告)日：2013-12-03
申请号：US12676511
申请日：2007-09-04
申请人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
发明人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
IPC分类号： A61K38/21 , A61K38/00 , A61K39/385 , C07K14/56
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
摘要： The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.
摘要翻译： 本发明涉及在具有Y型支链聚乙二醇（PEG）衍生物的特定Lys残基修饰的干扰素（IFN）-α2a及其制备方法，以及使用经单PEG修饰的IFN-α2a 药物中的氨基酸残基。
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3.发明申请INTERFERON ALPHA 2B MODIFIED BY POLYETHYLENE GLYCOL, THE PREPARATION AND USE THEREOF 有权由聚乙二醇改性的干燥素ALPHA，其制备及其用途公开(公告)号：US20110158943A1
公开(公告)日：2011-06-30
申请号：US12676525
申请日：2007-09-04
申请人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
发明人： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
IPC分类号： A61K38/21 , C07K14/565 , A61P37/02 , A61P11/06 , A61P35/00 , A61P31/12 , A61P31/14 , A61P35/02
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
摘要： The present invention relates to interferon-α2b modified with Y-shaped branched polyethylene glycol (PEG) at a single Lys residue and the preparation thereof. The peglated IFN-α2b can be used for the preparation of a medicament for treating a disease, e.g. viral infections such as Hepatitis C.
摘要翻译： 本发明涉及在单个Lys残基处用Y型支化聚乙二醇（PEG）修饰的干扰素-α2b及其制备。 聚乙二醇干扰素α2b可用于制备用于治疗疾病的药物，例如， 病毒感染如丙型肝炎
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