发明授权
US08604195B2 Substituted bicyclic piperidinyl- and piperazinyl-sulfonamides useful to inhibit 11β-hydroxysteroid dehydrogenase type-1
有权
用于抑制1型11β-羟类固醇脱氢酶的二取代的双环哌啶基和哌嗪基 - 磺酰胺
- 专利标题： Substituted bicyclic piperidinyl- and piperazinyl-sulfonamides useful to inhibit 11β-hydroxysteroid dehydrogenase type-1
- 专利标题（中）： 用于抑制1型11β-羟类固醇脱氢酶的二取代的双环哌啶基和哌嗪基 - 磺酰胺
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申请号： US12672825申请日： 2008-08-12
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公开(公告)号： US08604195B2公开(公告)日： 2013-12-10
- 发明人: Unmesh Shah , Craig D. Boyle , Samuel Chackalamannil
- 申请人： Unmesh Shah , Craig D. Boyle , Samuel Chackalamannil
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Richard S. Parr; Catherine D. Fitch
- 国际申请： PCT/US2008/009607 WO 20080812
- 国际公布： WO2009/023180 WO 20090219
- 主分类号： C07D451/06
- IPC分类号： C07D451/06 ; C07D471/08 ; A61K31/46 ; A61K31/529
摘要：
In its many embodiments, the present invention relates to a novel class of substituted bicyclic piperidinyl- and piperazinylsulfonamide compounds useful to inhibit 11β-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11β-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.
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