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    Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
    6.
    发明授权
    Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction 失效
    黄嘌呤的代谢物磷酸二酯酶5抑制剂及其衍生物可用于治疗勃起功能障碍

    公开(公告)号：US07312223B2

    公开(公告)日：2007-12-25

    申请号：US10901574

    申请日：2004-07-29

    申请人： Anima Ghosal ,  Wei Tong ,  Swapan K. Chowdhury ,  Shmuel Zbaida ,  Mark A. Wirth ,  Kevin B. Alton ,  James E. Patrick ,  Craig D. Boyle ,  Andrew Stamford

    发明人： Anima Ghosal ,  Wei Tong ,  Swapan K. Chowdhury ,  Shmuel Zbaida ,  Mark A. Wirth ,  Kevin B. Alton ,  James E. Patrick ,  Craig D. Boyle ,  Andrew Stamford

    IPC分类号： C07D473/06 ,  A61K31/522 ,  A61P9/10 ,  A61P9/12

    CPC分类号： C07D473/06

    摘要： The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.

    摘要翻译： 本发明涉及具有以下结构衍生物的黄嘌呤磷酸二酯酶5型抑制剂的代谢物及其制剂及其制备方法。 进一步公开的是治疗患者的生理障碍，症状或疾病的方法，包括向患者施用有效量的上述化合物，其中所述生理障碍，症状或疾病是泌尿生殖系统，心血管，脑血管或外周血管疾病， 心绞痛，高血压，血管成形术后再狭窄，内膜切除术，支架引入，脑中风，呼吸道疾病如与过敏相关的过敏性疾病，肺动脉高压，缺血性心脏病，糖耐量异常，糖尿病及其相关并发症，胰岛素抵抗 综合征，高血糖症，多囊卵巢综合征，肾小球疾病，肾功能不全，肾炎，管状间质性疾病，自身免疫性疾病，青光眼，肠蠕动，恶病质或癌症。