发明授权
- 专利标题: Use of an adrenal hormone-modifying agent
- 专利标题(中): 使用肾上腺激素调节剂
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申请号: US13521548申请日: 2011-01-13
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公开(公告)号: US08609862B2公开(公告)日: 2013-12-17
- 发明人: Qi-Ying Hu , Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Christoph Schumacher
- 申请人: Qi-Ying Hu , Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Christoph Schumacher
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 代理商 Cozette M McAvoy
- 国际申请: PCT/US2011/021100 WO 20110113
- 国际公布: WO2011/088188 WO 20110721
- 主分类号: A61K31/4188
- IPC分类号: A61K31/4188 ; C07D235/02
摘要:
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or —C(O)N(Ra)(Rb) wherein Ra and Rb are independently —(C1-C4)alkyl, or —(C1-C4)alkyl-(C5-C7)aryl, wherein each of Ra and Rb is optionally substituted by —(C1-C4)alkoxy; R1, R2, and R3, are independently hydrogen, halogen, cyano or —(C6-C10) aryl, wherein said —(C6-C10)aryl is optionally substituted by halogen, with the proviso that no more than one of R1, R2, and R3 is hydrogen; and R4 and R5 are hydrogen; or a pharmaceutically acceptable salt thereof.
公开/授权文献
- US20120295888A1 USE OF AN ADRENAL HORMONE-MODIFYING AGENT 公开/授权日:2012-11-22