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    Organic Compounds
    6.
    发明申请
    Organic Compounds 审中-公开
    有机化合物

    公开(公告)号：US20120277215A1

    公开(公告)日：2012-11-01

    申请号：US13540113

    申请日：2012-07-02

    申请人： Gary Michael Ksander ,  Erik Meredith ,  Lauren G. Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    发明人： Gary Michael Ksander ,  Erik Meredith ,  Lauren G. Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    IPC分类号： C07D487/04 ,  A61K31/5377 ,  A61K31/454 ,  C07D487/20 ,  C07D471/04 ,  A61K31/437 ,  A61K31/55 ,  A61P9/12 ,  A61P9/04 ,  A61P13/12 ,  A61P9/10 ,  A61P3/00 ,  A61P3/04 ,  A61P9/00 ,  A61P29/00 ,  A61P19/10 ,  A61P35/00 ,  A61P15/08 ,  A61K31/4188

    CPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

    摘要翻译： 本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。 因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后， 冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症 ，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。 最后，本发明还提供药物组合物。

    Organic compounds
    7.
    发明申请
    Organic compounds 有权
    有机化合物

    公开(公告)号：US20070049616A1

    公开(公告)日：2007-03-01

    申请号：US11508445

    申请日：2006-08-23

    申请人： Gary Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    发明人： Gary Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    IPC分类号： A61K31/4745 ,  A61K31/4188 ,  C07D471/02

    CPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

    摘要翻译： 本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。 因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后， 冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症 ，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。 最后，本发明还提供药物组合物。

    Organic compounds
    8.
    发明授权
    Organic compounds 有权
    有机化合物

    公开(公告)号：US09278969B2

    公开(公告)日：2016-03-08

    申请号：US14459567

    申请日：2014-08-14

    申请人： Gary Michael Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    发明人： Gary Michael Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    IPC分类号： C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4188 ,  A61K31/454 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/55

    CPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

    摘要翻译： 本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。 因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后， 冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症 ，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。 最后，本发明还提供药物组合物。

    Organic Compounds
    9.
    发明申请
    Organic Compounds 有权
    有机化合物

    公开(公告)号：US20140357621A1

    公开(公告)日：2014-12-04

    申请号：US14459567

    申请日：2014-08-14

    申请人： Gary Michael Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    发明人： Gary Michael Ksander ,  Erik Meredith ,  Lauren Monovich ,  Julien Papillon ,  Fariborz Firooznia ,  Qi-Ying Hu

    IPC分类号： C07D471/04 ,  A61K31/55 ,  A61K45/06 ,  A61K31/437 ,  C07D487/04 ,  A61K31/4188

    CPC分类号： C07D471/04 ,  A61K31/4188 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04

    摘要： The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

    摘要翻译： 本发明提供式I化合物：所述化合物是醛固酮合成酶和芳香酶的抑制剂，因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。 因此，式I化合物可用于治疗低钾血症，高血压，充血性心力衰竭，心房颤动，肾衰竭，特别是慢性肾衰竭，再狭窄，动脉粥样硬化，综合征X，肥胖症，肾病，心肌梗塞后， 冠状动脉心脏病，炎症，胶原蛋白形成增加，纤维化如心脏或心肌纤维化，以及高血压和内皮功能障碍后重塑，男子乳腺发育不良，骨质疏松症，前列腺癌，子宫内膜异位症，子宫肌瘤，功能障碍性子宫出血，子宫内膜增生，多囊卵巢疾病，不育症 ，纤维囊性乳腺疾病，乳腺癌和纤维囊性乳腺病。 最后，本发明还提供药物组合物。