发明授权
- 专利标题: Anti-IL-13Rα1 antibodies and their uses thereof
- 专利标题(中): 抗IL-13Rα1抗体及其用途
-
申请号: US12445753申请日: 2007-10-19
-
公开(公告)号: US08613925B2公开(公告)日: 2013-12-24
- 发明人: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- 申请人: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- 申请人地址: AU Parkville, Victoria
- 专利权人: CSL Limited
- 当前专利权人: CSL Limited
- 当前专利权人地址: AU Parkville, Victoria
- 代理机构: Licata & Tyrrell, P.C.
- 国际申请: PCT/US2007/081884 WO 20071019
- 国际公布: WO2008/060814 WO 20080522
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13Rα1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13Rα1-mediated activities are also disclosed.
公开/授权文献
- US20110052597A1 Anti-IL-13R Alpha1 Antibodies and Their Uses Thereof 公开/授权日:2011-03-03
信息查询