发明授权
US08628779B2 Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof
有权
携带人乳头状瘤病毒表位的重组蛋白质插入腺苷酸环化酶蛋白或其片段。 其治疗用途
- 专利标题： Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof
- 专利标题（中）： 携带人乳头状瘤病毒表位的重组蛋白质插入腺苷酸环化酶蛋白或其片段。 其治疗用途
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申请号： US11517313申请日： 2006-09-08
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公开(公告)号： US08628779B2公开(公告)日： 2014-01-14
- 发明人: Xavier-Edmond-Edouard Preville , Claude Leclerc , Daniel Ladant , Benedikt Timmerman
- 申请人： Xavier-Edmond-Edouard Preville , Claude Leclerc , Daniel Ladant , Benedikt Timmerman
- 申请人地址： FR Paris FR Labege-Innopole FR Paris FR Paris
- 专利权人： Institut Pasteur,Genticel,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique
- 当前专利权人： Institut Pasteur,Genticel,Institut National de la Sante et de la Recherche Medicale,Centre National de la Recherche Scientifique
- 当前专利权人地址： FR Paris FR Labege-Innopole FR Paris FR Paris
- 代理机构： Law Office of Salvatore Arrigo and Scott Lee, LLP
- 优先权： EP04290741 20040318
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/295 ; C07K14/235 ; C07K14/025
摘要：
The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
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