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1.发明授权Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof 有权插入腺苷酸环化酶蛋白或其片段的携带人乳头状瘤病毒表位的重组蛋白质的治疗用途公开(公告)号：US08637039B2
公开(公告)日：2014-01-28
申请号：US12977754
申请日：2010-12-23
IPC分类号： A61K39/12 , A61K39/295 , C07K14/235 , C07K14/025
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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2.发明申请Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof 有权携带人乳头状瘤病毒表位的重组蛋白质插入腺苷酸环化酶蛋白或其片段。 其治疗用途公开(公告)号：US20070072266A1
公开(公告)日：2007-03-29
申请号：US11517313
申请日：2006-09-08
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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3.发明申请RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMAVIRUS EPITOPES INSERTED IN AN ADENYLATE CYCLASE PROTEIN OR FRAGMENT THEREOF THERAPEUTIC USES THEREOF 有权重组蛋白携带人腺病毒外周血单核细胞插入腺苷酸蛋白或其片段，其治疗用途公开(公告)号：US20110171244A1
公开(公告)日：2011-07-14
申请号：US12977754
申请日：2010-12-23
IPC分类号： A61K39/12 , C12Q1/34 , C12N9/99 , C12N9/14 , C12N1/21 , C12N15/63 , A61K38/00 , A61K31/7088 , C07H21/04 , A61P31/12 , A61P37/02 , A61P35/00
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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4.发明授权Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof 有权携带人乳头状瘤病毒表位的重组蛋白质插入腺苷酸环化酶蛋白或其片段。 其治疗用途公开(公告)号：US08628779B2
公开(公告)日：2014-01-14
申请号：US11517313
申请日：2006-09-08
IPC分类号： A61K39/12 , A61K39/295 , C07K14/235 , C07K14/025
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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公开(公告)号：US07651842B2
公开(公告)日：2010-01-26
申请号：US10250664
申请日：2002-01-04
申请人： Benedikt Timmerman
发明人： Benedikt Timmerman
CPC分类号： A61K39/39 , A61K39/0002 , A61K39/0258 , A61K2039/541 , A61K2039/542 , A61K2039/55555 , A61K2039/55561 , Y02A50/388 , Y02A50/39 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/474 , Y02A50/484
摘要： The present invention relates to an Immunogenic Complex comprising Ribosomal Complex and Adhesion of a Microbe or Ribosomal Complex and a viral antigen. The Ribosomal Complex is composed of the subunits of ribosomes (50 S and 30 S subunits in bacteria and 60 S and 40 S subunits of eucaryotes), the ribosomal subunits generally retaining sufficient integrity to preserve substantially the double-stranded nature of the large r-RNA's (16 S and 23 S in bacteria; 18 S and 28 S in eukaryotic cytosol) contained in the ribosomal subunits.
摘要翻译： 本发明涉及包含核糖体复合物和微生物或核糖体复合物和病毒抗原的粘附的免疫原性复合物。 核糖体复合体由核糖体（细菌中的50S和30S亚基，真核生物的60S和40S亚基）的亚基组成，核糖体亚基通常保持足够的完整性以保持大r- 包含在核糖体亚基中的RNA（细菌中的16S和23S;真核细胞质中的18S和28S）。
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6.发明申请Composition for eliciting a specific ctl response, comprising a lympho-ablative compound and a molecule that contains antigenic sequences and targets professional antigen presenting cells 有权用于引发特定ct1应答的组合物，其包含淋巴消融化合物和含有抗原序列和靶向专业抗原呈递细胞的分子公开(公告)号：US20110097337A1
公开(公告)日：2011-04-28
申请号：US12310544
申请日：2007-08-31
IPC分类号： A61K39/395 , A61K39/00 , A61K39/02 , A61K39/04 , A61K38/51 , A61P35/00 , A61P37/02 , A61P37/04
CPC分类号： A61K45/06 , A61K38/164 , A61K38/51 , A61K39/0005 , A61K47/48261 , A61K47/4833 , A61K47/6415 , A61K47/646 , A61K2300/00
摘要： The present invention relates to a composition for eliciting a specific cytotoxic T lymphocyte (CTL) response against T cell epitopes in a mammal, which comprises a compound provoking lymphocytopenia, a molecule having selective affinity for professional antigen presenting cells (APC), wherein said molecule is associated to said T cell epitope, and optionally, a pharmaceutical acceptable carrier. Advantageously, the composition further contains an adjuvant. Said composition may be used in anti-infections and anti-cancer therapies.
摘要翻译： 本发明涉及用于引发针对哺乳动物中T细胞表位的特异性细胞毒性T淋巴细胞（CTL）应答的组合物，其包含引起淋巴细胞减少的化合物，对专业抗原呈递细胞（APC）具有选择性亲合力的分子，其中所述分子 与所述T细胞表位和任选的药学上可接受的载体相关。 有利地，组合物还含有佐剂。 所述组合物可用于抗感染和抗癌治疗。
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7.发明授权Composition for eliciting a specific CTL response, comprising a lympho-ablative compound and a molecule that contains antigenic sequences and targets professional antigen presenting cells 有权用于引发特异性CTL应答的组合物，其包含淋巴消融化合物和含有抗原性序列和靶向专业抗原呈递细胞的分子公开(公告)号：US09486524B2
公开(公告)日：2016-11-08
申请号：US12310544
申请日：2007-08-31
CPC分类号： A61K45/06 , A61K38/164 , A61K38/51 , A61K39/0005 , A61K47/48261 , A61K47/4833 , A61K47/6415 , A61K47/646 , A61K2300/00
摘要： The present invention relates to a composition for eliciting a specific cytotoxic T lymphocyte (CTL) response against T cell epitopes in a mammal, which comprises a compound provoking lymphocytopenia, a molecule having selective affinity for professional antigen presenting cells (APC), wherein said molecule is associated to said T cell epitope, and optionally, a pharmaceutical acceptable carrier. Advantageously, the composition further contains an adjuvant. Said composition may be used in anti-infections and anti-cancer therapies.
摘要翻译： 本发明涉及用于引发针对哺乳动物中T细胞表位的特异性细胞毒性T淋巴细胞（CTL）应答的组合物，其包含引起淋巴细胞减少的化合物，对专业抗原呈递细胞（APC）具有选择性亲合力的分子，其中所述分子 与所述T细胞表位和任选的药学上可接受的载体相关。 有利地，组合物还含有佐剂。 所述组合物可用于抗感染和抗癌疗法。
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