发明授权
- 专利标题： PAI-1 inhibitor
- 专利标题（中）： PAI-1抑制剂
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申请号： US12422099申请日： 2009-04-10
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公开(公告)号： US08633245B2公开(公告)日： 2014-01-21
- 发明人: Youichi Yamaguchi , Takeshi Yanase , Susumu Muto , Akiko Itai
- 申请人： Youichi Yamaguchi , Takeshi Yanase , Susumu Muto , Akiko Itai
- 申请人地址： JP Tokyo
- 专利权人： Institute of Medicinal Molecular Design, Inc.
- 当前专利权人： Institute of Medicinal Molecular Design, Inc.
- 当前专利权人地址： JP Tokyo
- 代理机构： Tarolli, Sundheim, Covell & Tummino LLP
- 主分类号： A61K31/19
- IPC分类号： A61K31/19 ; C07C51/00
摘要：
The compound represented by the following formula (I) and the like have PAI-1 inhibition activity;wherein: R1 represents a C6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents —N—C(═O)—CO2H or the like; when m is 1, G represents an oxygen atom or the like; R2 represents a C6-10 aryl group which may be substituted or the like; E represents the following formula (II) wherein one of R31, R32, R33 and R34 represents the formula R1-T-, each of the other three independently represents a hydrogen atom or the like, and R35 represents the formula —X—Y′, a hydrogen atom or the like; X represents —CH2— or the like; Y′ represents a carboxy group or the like; M represents a single bond or the like.
公开/授权文献
- US20090312315A1 PAI-1 INHIBITOR 公开/授权日：2009-12-17
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