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14 条记录 (耗时 0.046 秒)

    Carboxilic acid derivatives
    2.
    发明授权
    Carboxilic acid derivatives 失效
    羧酸衍生物

    公开(公告)号：US08044236B2

    公开(公告)日：2011-10-25

    申请号：US11870718

    申请日：2007-10-11

    申请人： Youichi Yamaguchi ,  Takeshi Yanase ,  Susumu Muto ,  Akiko Itai

    发明人： Youichi Yamaguchi ,  Takeshi Yanase ,  Susumu Muto ,  Akiko Itai

    IPC分类号： C07C65/00 ,  C07C59/40

    CPC分类号： C07C51/00 ,  C07C59/64 ,  C07C65/24 ,  C07C65/28 ,  C07C205/06 ,  C07C205/34 ,  C07C217/86 ,  C07C235/80 ,  C07C255/37

    摘要： A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R1 represents a C6-10 aryl group; or a substituted C6-10 aryl group, R2 represents a C6-10 aryl group; or a C6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, nitro group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a phenyl group and carboxy group, X represents —CH2—, —CH2CH2—, —CH═CH— or —N(R3)—C(═O)—, Y represents carboxy group or a bioisostere of carboxy group, R3 represents hydrogen atom, a C1-4 alkyl group or a C7-12 aralkyl group, m represents 0 or 1.

    摘要翻译： 具有对纤维蛋白溶酶原激活物抑制剂-1（PAI-1）具有抑制作用的由以下通式（I）表示的化合物或其盐，或其水合物或其溶剂化物：其中R1表示C6-10芳基; 或取代的C6-10芳基，R2表示C6-10芳基; 或被选自卤素原子，硝基，C 1-6烷基，卤代C 1-6烷基，C 1-6烷氧基，卤代 C 1-6烷氧基，苯基和羧基，X表示-CH 2 - ， - CH 2 CH 2 - ， - CH = CH-或-N（R 3）-C（= O） - ，Y表示羧基或生物电子 羧基，R 3表示氢原子，C 1-4烷基或C 7-12芳烷基，m表示0或1。

    N-phenyloxamide derivatives
    4.
    发明授权
    N-phenyloxamide derivatives 有权
    N-苯基酰胺衍生物

    公开(公告)号：US07884234B2

    公开(公告)日：2011-02-08

    申请号：US11870741

    申请日：2007-10-11

    申请人： Youichi Yamaguchi ,  Takeshi Yanase ,  Susumu Muto ,  Akiko Itai

    发明人： Youichi Yamaguchi ,  Takeshi Yanase ,  Susumu Muto ,  Akiko Itai

    IPC分类号： C07C229/00

    CPC分类号： C07D307/91 ,  C07C233/56 ,  C07C255/60 ,  C07C323/41

    摘要： A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R1 represents a C6-10 aryl group; or a C6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, cyano group, nitro group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group and a C1-6 alkylsulfanyl group, R2 represents a C6-10 aryl group; or a C6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, hydroxy group, a C1-6 alkyl group, a halogenated C1-6 alkyl group, a C1-6 alkoxy group, a halogenated C1-6 alkoxy group, a C1-6 alkylsulfanyl group and phenyl group, X represents a single bond or oxygen atom, Z represents a phenylene group or a substituted phenylene group, m represents 0 or 1.

    摘要翻译： 具有对纤维蛋白溶酶原激活物抑制剂-1（PAI-1）具有抑制作用的由以下通式（I）表示的化合物或其盐，或其水合物或其溶剂化物：其中R1表示C6-10芳基; 或被选自卤素原子，氰基，硝基，C 1-6烷基，卤代C 1-6烷基，C 1-6烷氧基中的一个或多个基团取代的C 6-10芳基 卤代C 1-6烷氧基和C 1-6烷硫基，R 2表示C 6-10芳基; 或被选自卤素原子，羟基，C 1-6烷基，卤代C 1-6烷基，C 1-6烷氧基，卤代的基团取代的C 6-10芳基 C 1-6烷氧基，C 1-6烷硫基和苯基，X表示单键或氧原子，Z表示亚苯基或取代亚苯基，m表示0或1。

    Balloon catheter
    7.
    发明授权
    Balloon catheter 有权
    气球导管

    公开(公告)号：US09592369B2

    公开(公告)日：2017-03-14

    申请号：US12438118

    申请日：2007-08-21

    申请人： Youichi Yamaguchi

    发明人： Youichi Yamaguchi

    IPC分类号： A61M29/02 ,  A61M25/10 ,  A61L29/08 ,  A61M25/01

    CPC分类号： A61M25/104 ,  A61L29/085 ,  A61M25/1027 ,  A61M25/1029 ,  A61M2025/018 ,  A61M2025/0183 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1088 ,  A61M2205/32

    摘要： A balloon catheter having multiple tubular members, an adaptor member connected thereto and a balloon for dilation of constricted blood vessel, wherein the peeling strength of the balloon surfaces when adheres to each other is 0.06 N or more and the modulus of the balloon in the axial direction is 100 N/mm2 or more, and wherein the coated resin composition contains a hydrophilic resin that is lubricating when wet. Furthermore, the outer surface of the balloon is made of a polyamide elastomer resin composition having a durometer hardness of 55 D or less. Thus, there can be provided a balloon catheter excelling in handling property, for which keeping the balloon highly penetrable through the stricture site as the accordion phenomenon of the balloon is prevented, and simultaneously preserving the other properties of the balloon (flexibility of balloon, wrapping dimension, and dilation/shrinkage response etc.).

    摘要翻译： 具有多个管状构件的球囊导管，连接到其上的适配器构件和用于扩张收缩血管的气囊，其中当彼此粘附时球囊表面的剥离强度为0.06N以上，并且球囊在轴向上的模量 方向为100N / mm 2以上，并且其中涂布的树脂组合物含有在湿润时润滑的亲水性树脂。 此外，球囊的外表面由硬度为硬度为55D以下的聚酰胺弹性体树脂组合物制成。 因此，可以提供一种气囊导管，其处理性能优异，保护气囊能够通过狭窄部位高度穿透，因为防止气囊的手风琴现象，同时保持球囊的其他特性（球囊的柔韧性 尺寸和膨胀/收缩响应等）。

    Device for continuously measuring and correcting tackiness of sheet of unvulcanized rubber material
    8.
    发明授权
    Device for continuously measuring and correcting tackiness of sheet of unvulcanized rubber material 失效
    用于连续测量和校正未硫化橡胶材料片材粘合性的装置

    公开(公告)号：US5049057A

    公开(公告)日：1991-09-17

    申请号：US519522

    申请日：1990-05-04

    申请人： Youichi Yamaguchi ,  Shohei Nakayama ,  Shigeru Shinoda

    发明人： Youichi Yamaguchi ,  Shohei Nakayama ,  Shigeru Shinoda

    IPC分类号： G01N19/04 ,  G01N33/44

    CPC分类号： G01N19/04 ,  G01N33/445

    摘要： A device for continuously measuring and correcting a tackiness of a sheet of rubber material including a feeding unit for continuously feeding an unvulcanized rubber sheet along a flat support surface and a rotatable roller in contact with the unvulcanized rubber sheet, whereby the roller is rotated by the movement of the unvulcanized rubber sheet, and entrained in the sheet feed direction due to a tackiness of the unvulcanized rubber sheet. A load cell is connected to the roller via a linkage, for measuring a resistance to the rolling of the roller, i.e., a change of a position of the roller entrained in the sheet feed direction. The device also includes a correcting unit for correcting a tackiness of the sheet of unvulcanized rubber material, the correcting unit being controlled by a control element in response to an output from the measuring unit, in such a manner that the correcting unit acts on the surface of the unvulcanized rubber sheet of rubber material when an output from the measuring unit is outside a predetermined range of tackiness.

    摘要翻译： 一种用于连续地测量和校正橡胶材料片的粘性的装置，包括用于沿着平坦支撑表面连续供给未硫化橡胶片的进料单元和与未硫化橡胶片接触的可旋转辊，由此辊由 未硫化橡胶片的移动，并且由于未硫化橡胶片的粘性而夹带在片材进给方向。 负载传感器通过连杆连接到辊子上，用于测量辊的滚动阻力，即夹带在送纸方向上的辊的位置的变化。 该装置还包括校正单元，用于校正未硫化橡胶材料片的粘性，校正单元由控制元件响应于来自测量单元的输出而被控制，使得校正单元作用在表面上 当来自测量单元的输出超出预定的粘性范围时，橡胶材料的未硫化橡胶片。

    Balloon Catheter
    9.
    发明申请
    Balloon Catheter 有权
    气球导管

    公开(公告)号：US20100174235A1

    公开(公告)日：2010-07-08

    申请号：US12438118

    申请日：2007-08-21

    申请人： Youichi Yamaguchi

    发明人： Youichi Yamaguchi

    IPC分类号： A61M29/02

    CPC分类号： A61M25/104 ,  A61L29/085 ,  A61M25/1027 ,  A61M25/1029 ,  A61M2025/018 ,  A61M2025/0183 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1088 ,  A61M2205/32

    摘要： A balloon catheter having multiple tubular members, an adaptor member connected thereto and a balloon for dilation of constricted blood vessel, wherein the peeling strength of the balloon surfaces when adheres to each other is 0.06 N or more and the modulus of the balloon in the axial direction is 100 N/mm2 or more, and wherein the coated resin composition contains a hydrophilic resin that is lubricating when wet. Furthermore, the outer surface of the balloon is made of a polyamide elastomer resin composition having a durometer hardness of 55 D or less. Thus, there can be provided a balloon catheter excelling in handling property, for which keeping the balloon highly penetrable through the stricture site as the accordion phenomenon of the balloon is prevented, and simultaneously preserving the other properties of the balloon (flexibility of balloon, wrapping dimension, and dilation/shrinkage response etc.).

    摘要翻译： 具有多个管状构件的球囊导管，连接到其上的适配器构件和用于扩张收缩血管的气囊，其中当彼此粘附时球囊表面的剥离强度为0.06N以上，并且球囊在轴向上的模量 方向为100N / mm 2以上，并且其中涂布的树脂组合物含有在湿润时润滑的亲水性树脂。 此外，球囊的外表面由硬度为硬度为55D以下的聚酰胺弹性体树脂组合物制成。 因此，可以提供一种气囊导管，其处理性能优异，保护气囊能够通过狭窄部位高度穿透，因为防止气囊的手风琴现象，同时保持球囊的其他特性（球囊的柔韧性 尺寸和膨胀/收缩响应等）。