发明授权
US08637539B2 Remedies for neuropathic pain and model animals of neuropathic pain
有权
神经性疼痛和模型动物的神经性疼痛的补救措施
- 专利标题： Remedies for neuropathic pain and model animals of neuropathic pain
- 专利标题（中）： 神经性疼痛和模型动物的神经性疼痛的补救措施
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申请号： US11206489申请日： 2005-08-18
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公开(公告)号： US08637539B2公开(公告)日： 2014-01-28
- 发明人: Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
- 申请人： Hiroshi Nagase , Takashi Endo , Kuniaki Kawamura , Toshiaki Tanaka , Tomohiko Suzuki , Tsutomu Suzuki , Yasushi Kuraishi , Kimiyasu Shiraki
- 申请人地址： JP
- 专利权人： Toray Industries, Inc.
- 当前专利权人： Toray Industries, Inc.
- 当前专利权人地址： JP
- 代理机构： DLA Piper LLP (US)
- 优先权： JP11/236778 19990824
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; A61K31/44
摘要：
The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.
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