发明授权
US08637666B2 Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
失效
制备可用作蛋白激酶抑制剂的嘧啶衍生物的方法
- 专利标题： Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
- 专利标题（中）： 制备可用作蛋白激酶抑制剂的嘧啶衍生物的方法
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申请号： US13424736申请日： 2012-03-20
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公开(公告)号： US08637666B2公开(公告)日： 2014-01-28
- 发明人: Jean-Damien Charrier , Steven Durrant , David Kay
- 申请人： Jean-Damien Charrier , Steven Durrant , David Kay
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理商 Rory C. Stewart
- 主分类号： C07D487/12
- IPC分类号： C07D487/12
摘要：
A method of preparing a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and claims, comprises the step of: a) cyclizing a compound represented by Structural Formula A: under suitable reductive cyclization conditions to form a compound represented by Structural Formula B: wherein R10 is LG1 or —X1R1, and -LG1 is a suitable leaving group; and b) optionally, when R10 of Structural Formula (B) is LG1, further comprising the step of replacing the -LG1 of Structural Formula (B) with —X1R1 to form the compound represented by Structural Formula (I).
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