发明授权
US08642010B2 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
有权
KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
- 专利标题： KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
- 专利标题（中）： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
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申请号： US12480578申请日： 2009-06-08
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公开(公告)号： US08642010B2公开(公告)日： 2014-02-04
- 发明人: Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
- 申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
- 申请人地址： US MA Burlington CH Manno
- 专利权人： Dyax Corp.,Bracco Suisse SA
- 当前专利权人： Dyax Corp.,Bracco Suisse SA
- 当前专利权人地址： US MA Burlington CH Manno
- 代理机构： Pearl Cohen Zedek Latzer Baratz LLP
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61B8/00
摘要：
The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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