发明授权
- 专利标题: Melt extrusion of salts of active ingredients
- 专利标题(中): 熔融挤出活性成分的盐
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申请号: US10498829申请日: 2003-01-30
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公开(公告)号: US08642089B2公开(公告)日: 2014-02-04
- 发明人: Hans-Ulrich Petereit , Christian Meier , Andreas Gryczke
- 申请人: Hans-Ulrich Petereit , Christian Meier , Andreas Gryczke
- 申请人地址: DE Darmstadt
- 专利权人: Evonik Roehm GmbH
- 当前专利权人: Evonik Roehm GmbH
- 当前专利权人地址: DE Darmstadt
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权: DE10208344 20020227
- 国际申请: PCT/EP03/00935 WO 20030130
- 国际公布: WO03/072083 WO 20030904
- 主分类号: A61K9/16
- IPC分类号: A61K9/16 ; A61K9/00 ; A61K9/14 ; A61K9/50 ; A61K47/32
摘要:
The invention relates to a method for producing active ingredient-containing granules or powders involving the following steps: a) melting a mixture consisting of a pharmaceutical active ingredient and of a (meth)acrylate copolymer, which is comprised of 40 to 75 wt. % of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and can be comprised of 25 to 60 wt. % (meth)acrylate monomers having an anionic group in the alkyl radial; b) extruding the mixture, and; c) comminuting the extrudate to form a granule or powder. The inventive method is characterized in that the active ingredient is the salt of an alkaline substance, and in that the pH value, which can be measured on the obtained powder or granule, is equal to or less than pH 7.0. The invention also relates to pharmaceutical dosage forms or precursors thereof, which can be produced using the inventive method.
公开/授权文献
- US20040253314A1 Melt extrusion of salts of active ingredients 公开/授权日:2004-12-16
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