发明授权
- 专利标题： Analysis of ex vivo cells for disease state detection and therapeutic agent selection and monitoring
- 专利标题（中）： 疾病状态检测和治疗剂选择和监测的离体细胞分析
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申请号： US12993826申请日： 2008-12-01
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公开(公告)号： US08652798B2公开(公告)日： 2014-02-18
- 发明人: James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
- 申请人： James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Foley & Lardner LLP
- 代理商 Cliff Z. Liu
- 国际申请： PCT/US2008/085194 WO 20081201
- 国际公布： WO2009/142661 WO 20091126
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02 ; B82B3/00
摘要：
Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.
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