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1.发明申请ANALYSIS OF EX VIVO CELLS FOR DISEASE STATE DETECTION AND THERAPEUTIC AGENT SELECTION AND MONITORING 有权用于疾病状态检测和治疗药物选择和监测的EXVIV细胞分析公开(公告)号：US20110070604A1
公开(公告)日：2011-03-24
申请号：US12993826
申请日：2008-12-01
Applicant: James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
Inventor： James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
CPC classification number: G01Q30/025 , B82Y15/00 , B82Y35/00 , G01Q20/00 , G01Q30/14 , G01Q60/366 , Y10S977/92
Abstract: Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.
Abstract translation: 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。
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2.发明授权Analysis of ex vivo cells for disease state detection and therapeutic agent selection and monitoring 有权疾病状态检测和治疗剂选择和监测的离体细胞分析公开(公告)号：US08652798B2
公开(公告)日：2014-02-18
申请号：US12993826
申请日：2008-12-01
Applicant: James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
Inventor： James K. Gimzewski , Sarah E. Cross , Yusheng Jin , Jianyu Rao
CPC classification number: G01Q30/025 , B82Y15/00 , B82Y35/00 , G01Q20/00 , G01Q30/14 , G01Q60/366 , Y10S977/92
Abstract: Described herein is the analysis of nanomechanical characteristics of cells. In particular, changes in certain local nanomechanical characteristics of ex vivo human cells can correlate with presence of a human disease, such as cancer, as well as a particular stage of progression of the disease. Also, for human patients that are administered with a therapeutic agent, changes in local nanomechanical characteristics of ex vivo cells collected from the patients can correlate with effectiveness of the therapeutic agent in terms of impeding or reversing progression of the disease. By exploiting this correlation, systems and related methods can be advantageously implemented for disease state detection and therapeutic agent selection and monitoring.
Abstract translation: 这里描述的是细胞的纳米机械特性的分析。 特别地，离体人细胞的某些局部纳米机械特征的变化可以与人类疾病如癌症的存在以及疾病进展的特定阶段相关联。 此外，对于施用治疗剂的人类患者，从患者收集的离体细胞的局部纳米机械特征的变化可以与治疗剂在阻碍或逆转疾病进展方面的有效性相关。 通过利用这种相关性，系统和相关方法可以有利地实现用于疾病状态检测和治疗剂选择和监测。
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