发明授权
US08652837B2 Method and means for producing high titer, safe, recombinant lentivirus vectors
有权
生产高滴度,安全,重组慢病毒载体的方法和方法
- 专利标题: Method and means for producing high titer, safe, recombinant lentivirus vectors
- 专利标题(中): 生产高滴度,安全,重组慢病毒载体的方法和方法
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申请号: US11781094申请日: 2007-07-20
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公开(公告)号: US08652837B2公开(公告)日: 2014-02-18
- 发明人: Luigi Naldini , Thomas Dull , Anatoly Bukovsky , Deborah A. Farson , Rochelle Witt
- 申请人: Luigi Naldini , Thomas Dull , Anatoly Bukovsky , Deborah A. Farson , Rochelle Witt
- 申请人地址: US CT Greenwich
- 专利权人: GBP IP, LLC
- 当前专利权人: GBP IP, LLC
- 当前专利权人地址: US CT Greenwich
- 代理机构: Jones Day
- 主分类号: C12N15/00
- IPC分类号: C12N15/00 ; C12N15/85
摘要:
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.