发明授权
- 专利标题： Antibody conjugates
- 专利标题（中）： 抗体缀合物
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申请号： US12381638申请日： 2009-03-13
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公开(公告)号： US08658389B2公开(公告)日： 2014-02-25
- 发明人: Christopher Bieniarz , Jennifer Wong , Mark Lefever , Jerome W. Kosmeder, II , Julia Ashworth-Sharpe , Casey A. Kernag
- 申请人： Christopher Bieniarz , Jennifer Wong , Mark Lefever , Jerome W. Kosmeder, II , Julia Ashworth-Sharpe , Casey A. Kernag
- 申请人地址： US AZ Tucson
- 专利权人： Ventana Medical Systems, Inc.
- 当前专利权人： Ventana Medical Systems, Inc.
- 当前专利权人地址： US AZ Tucson
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： G01N33/535
- IPC分类号： G01N33/535 ; G01N33/53 ; G01N33/532 ; G01N21/76
摘要：
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
公开/授权文献
- US20090176253A1 Antibody conjugates 公开/授权日：2009-07-09
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