- 专利标题: 2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
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申请号: US13123761申请日: 2009-10-22
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公开(公告)号: US08658657B2公开(公告)日: 2014-02-25
- 发明人: Shuji Yonezawa , Yuuji Kooriyama , Gaku Sakaguchi
- 申请人: Shuji Yonezawa , Yuuji Kooriyama , Gaku Sakaguchi
- 申请人地址: JP Osaka
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Hamre, Schumann, Mueller & Larson, P.C.
- 优先权: JP2008-272305 20081022
- 国际申请: PCT/JP2009/068200 WO 20091022
- 国际公布: WO2010/047372 WO 20100429
- 主分类号: A01N43/54
- IPC分类号: A01N43/54 ; A61K31/505 ; C07D239/02
摘要:
The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.
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