A self-inflating tire system includes a compression actuator assembly mounted to a tire carcass for compressing air for delivery to a tire cavity. The compression actuator assembly includes a hollow containment body formed from a resilient deformable material composition and containing a quantity of a non-compressible medium. The containment body is affixed to a relatively high flex-deformation region of the tire carcass and reciprocally transforms between a deformed state and a non-deformed state responsive to deformation and recovery of the tire high flex-deformation region in a rolling tire. Accordingly, the containment body in the deformed state displaces a pressurized displaced quantity of the non-compressible medium which generates a compression force for application to a volume of air delivered to the tire cavity. A pump assembly affixes to the tire carcass and includes valves for reciprocally opening and closing the inlet opening and the outlet opening of a compressor body synchronously with the cyclic transformation of the containment body.