发明授权
US08664191B2 Use of two microRNA moleculars in lung cancer prognosis and medicine preparation
有权
在肺癌预后和药物制备中使用两种microRNA分子
- 专利标题： Use of two microRNA moleculars in lung cancer prognosis and medicine preparation
- 专利标题（中）： 在肺癌预后和药物制备中使用两种microRNA分子
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申请号： US13382686申请日： 2009-07-09
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公开(公告)号： US08664191B2公开(公告)日： 2014-03-04
- 发明人: Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
- 申请人： Qimin Zhan , Lühua Wang , Nan Bi , Yongmei Song , Jianzhong Cao , Wenyang Liu
- 申请人地址： CN
- 专利权人： Cancer Institute, Chinese Academy of Medical Services
- 当前专利权人： Cancer Institute, Chinese Academy of Medical Services
- 当前专利权人地址： CN
- 代理机构： Schwegman, Lundberg & Woessner, P.A.
- 国际申请： PCT/CN2009/072695 WO 20090709
- 国际公布： WO2011/003237 WO 20110113
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/68 ; C07H21/02 ; C07H21/04
摘要：
The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.
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