公开(公告)号：US08664191B2

公开(公告)日：2014-03-04

申请号：US13382686

申请日：2009-07-09

申请人： Qimin Zhan ,  Lühua Wang ,  Nan Bi ,  Yongmei Song ,  Jianzhong Cao ,  Wenyang Liu

发明人： Qimin Zhan ,  Lühua Wang ,  Nan Bi ,  Yongmei Song ,  Jianzhong Cao ,  Wenyang Liu

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12N15/113 ,  A61K48/00 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.

摘要翻译： 本发明涉及两种microRNA在检测肺癌预后和药物制剂中的应用。 特别地，本发明涉及包含两个小RNA分子microRNA-150和microRNA-886-3p的组合物，包含用于检测肺癌预后的组合物和用于制备用于抑制哺乳动物和人肺癌转移的药物的装置。 具体来说，可以将microRNA-150和microRNA-886-3p的表达水平作为肺癌预后的预后标准，其中高表达水平的基因组合表示有利的治疗作用。 本发明还涉及检测哺乳动物和人肺癌中microRNA-150和microRNA-886-3p的表达水平的装置，以及检测样品中microRNA-150和microRNA-886-3p的表达水平的方法。

公开(公告)号：US20120220644A1

公开(公告)日：2012-08-30

申请号：US13382686

申请日：2009-07-09

申请人： Qimin Zhan ,  Lühua Wang ,  Nan Bi ,  Yongmei Song ,  Jianzhong Cao ,  Wenyang Liu

发明人： Qimin Zhan ,  Lühua Wang ,  Nan Bi ,  Yongmei Song ,  Jianzhong Cao ,  Wenyang Liu

IPC分类号： A61K31/7088 ,  C40B30/04 ,  A61P35/00 ,  C40B40/06

CPC分类号： C12N15/113 ,  A61K48/00 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to use of two microRNAs in detection of lung cancer prognosis and in medicine preparation. Particularly, the invention relates to a composition comprising two small RNA molecules microRNA-150 and microRNA-886-3p, a device comprising the composition used in detection of lung cancer prognosis and in preparation of medicaments for inhibiting mammal and human lung cancer metastasis. Specifically, the expression levels of microRNA-150 and microRNA-886-3p can be used as the prognostic criteria of lung cancer prognosis, wherein high expression level of the gene combination indicates favorable therapeutic effect. The invention also relates to a device detecting the expression levels of microRNA-150 and microRNA-886-3p in mammalian and human lung cancer and a method for detecting the expression levels of microRNA-150 and microRNA-886-3p in samples.

摘要翻译： 本发明涉及两种microRNA在检测肺癌预后和药物制剂中的应用。 特别地，本发明涉及包含两个小RNA分子microRNA-150和microRNA-886-3p的组合物，包含用于检测肺癌预后的组合物和用于制备用于抑制哺乳动物和人肺癌转移的药物的装置。 具体来说，可以将microRNA-150和microRNA-886-3p的表达水平作为肺癌预后的预后标准，其中高表达水平的基因组合表示有利的治疗作用。 本发明还涉及检测哺乳动物和人肺癌中microRNA-150和microRNA-886-3p的表达水平的装置，以及检测样品中microRNA-150和microRNA-886-3p的表达水平的方法。