Invention Grant
US08664199B2 Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
有权
用于逆转疏水改性的生物聚合物和囊泡或细胞膜之间相互作用的方法和系统
- Patent Title: Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
- Patent Title (中): 用于逆转疏水改性的生物聚合物和囊泡或细胞膜之间相互作用的方法和系统
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Application No.: US13209399Application Date: 2011-08-13
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Publication No.: US08664199B2Publication Date: 2014-03-04
- Inventor: Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
- Applicant: Matthew Dowling , Srinivasa R. Raghavan , Rakesh Kumar
- Applicant Address: US MD College Park
- Assignee: University of Maryland, College Park
- Current Assignee: University of Maryland, College Park
- Current Assignee Address: US MD College Park
- Agency: Whiteford, Taylor & Preston, LLP
- Agent Joseph L. Morales
- Main IPC: A61K31/722
- IPC: A61K31/722
Abstract:
A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
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