公开(公告)号：US08664199B2

公开(公告)日：2014-03-04

申请号：US13209399

申请日：2011-08-13

Applicant: Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

Inventor： Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

IPC: A61K31/722

CPC classification number: A61K31/724 ,  A61L15/28 ,  A61L15/42 ,  A61L26/0023 ,  A61L26/0061 ,  A61L26/0076 ,  A61L2300/232 ,  A61L2400/04

Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.

Abstract translation: 疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。 连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。 超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。

公开(公告)号：US08932560B2

公开(公告)日：2015-01-13

申请号：US12231571

申请日：2008-09-04

Applicant: Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

Inventor： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC: A61B5/055 ,  A61F2/00 ,  A61L15/00 ,  C08B37/08 ,  A61K47/48

CPC classification number: C08B15/00 ,  A61K47/61 ,  A61K47/69 ,  C08B37/0084

Abstract: A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

公开(公告)号：US20120252703A1

公开(公告)日：2012-10-04

申请号：US13310579

申请日：2011-12-02

Applicant: Matthew Dowling ,  Srinivasa R. Raghavan ,  Neeraja Dashaputre ,  Douglas Stephen English ,  Vishal Javvaji ,  Gregory F. Payne ,  Philip R. DeShong

Inventor： Matthew Dowling ,  Srinivasa R. Raghavan ,  Neeraja Dashaputre ,  Douglas Stephen English ,  Vishal Javvaji ,  Gregory F. Payne ,  Philip R. DeShong

IPC: G01N33/533 ,  C25D9/02 ,  C25D5/34 ,  C40B60/08

CPC classification number: A61F13/00017 ,  A61F13/00063 ,  A61L15/28 ,  A61L15/44 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/626 ,  G01N33/5432 ,  G01N33/5436 ,  G01N33/5438 ,  G01N33/548 ,  Y10T436/11 ,  C08L5/08

Abstract: A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.

Abstract translation: 一种生物传感器，包括涂覆有已经电沉积在基底上的改性壳聚糖生物聚合物的导电基底，其中所述改性的壳聚糖生物聚合物包含至少一个囊泡结合分子。 通过将改性的壳聚糖生物聚合物电沉积在基材上的方法制造生物传感器。 该方法还用于通过将壳聚糖电沉积在基底上并随后在电沉积之后从基底上去除膜来制造改性的壳聚糖生物聚合物膜。 所得薄膜可用于绷带以治疗各种类型的伤口。 生物传感器也可用于检测样品中的各种分析物。

公开(公告)号：US20110280857A1

公开(公告)日：2011-11-17

申请号：US12946818

申请日：2010-11-15

Applicant: Matthew Dowling ,  Srinivasa Raghavan

Inventor： Matthew Dowling ,  Srinivasa Raghavan

IPC: A61K31/722 ,  A61K38/48 ,  A61M35/00 ,  A61K31/734 ,  A61P7/04 ,  A61K31/717 ,  A61K38/36

CPC classification number: A61M35/003 ,  A61L24/0026 ,  A61L26/0076 ,  A61L2400/04

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract translation: 公开了一种用于可压缩和不可压缩（腔内）急性伤口的可喷雾聚合物泡沫止血剂。 泡沫包括疏水改性的聚合物，例如hm-壳聚糖或其它两亲性聚合物，其将自身锚定在伤口附近的细胞膜中。 通过从用液化气推进剂加压的罐中快速膨胀，泡沫能够进入受损的体腔和稳定的出血。 创建的密封件足够强大以防止来自这些空腔的血液的损失。 疏水改性聚合物固有地防止微生物感染，并且适合于正常伤口代谢期间所需的氧传递。 两亲聚合物形成具有血细胞的固体凝胶网络，以产生防止血液丧失的物理凝血机制。

公开(公告)号：US08858883B2

公开(公告)日：2014-10-14

申请号：US13310579

申请日：2011-12-02

Applicant: Matthew Dowling ,  Srinivasa R. Raghavan ,  Neeraja Dashaputre ,  Douglas Stephen English ,  Vishal Javvaji ,  Gregory F. Payne ,  Philip R. DeShong

Inventor： Matthew Dowling ,  Srinivasa R. Raghavan ,  Neeraja Dashaputre ,  Douglas Stephen English ,  Vishal Javvaji ,  Gregory F. Payne ,  Philip R. DeShong

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  A61L15/44 ,  A61F13/00 ,  G01N33/543 ,  A61L15/28 ,  G01N33/548

CPC classification number: A61F13/00017 ,  A61F13/00063 ,  A61L15/28 ,  A61L15/44 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/626 ,  G01N33/5432 ,  G01N33/5436 ,  G01N33/5438 ,  G01N33/548 ,  Y10T436/11 ,  C08L5/08

Abstract: A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle binding molecule. The biosensor is manufactured by a method where a modified chitosan biopolymer is electrodeposited on a substrate. The method is also used to manufacture a modified chitosan biopolymer film by electrodeposition of the chitosan on the substrate and later removing the film from the substrate after electrodeposition. The resulting film can be used in bandages to treat various types of wounds. The biosensor can also be used to detect various analytes in samples.

Abstract translation: 一种生物传感器，包括涂覆有已经电沉积在基底上的改性壳聚糖生物聚合物的导电基底，其中所述改性的壳聚糖生物聚合物包含至少一个囊泡结合分子。 通过将改性的壳聚糖生物聚合物电沉积在基材上的方法制造生物传感器。 该方法还用于通过将壳聚糖电沉积在基底上并随后在电沉积之后从基底上去除膜来制造改性的壳聚糖生物聚合物膜。 所得薄膜可用于绷带以治疗各种类型的伤口。 生物传感器也可用于检测样品中的各种分析物。

公开(公告)号：US20090062849A1

公开(公告)日：2009-03-05

申请号：US12231571

申请日：2008-09-04

Applicant: Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

Inventor： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC: A61L26/00 ,  A61M11/00

CPC classification number: C08B15/00 ,  A61K47/61 ,  A61K47/69 ,  C08B37/0084

Abstract: A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

Abstract translation: 公开了止血组织密封剂海绵和用于急性创伤的喷雾剂。 海绵包括疏水改性的聚合物，其将自身锚定在伤口附近的细胞膜内。 该密封足够坚固以基本上防止海绵边界内的血液损失，但足够弱到基本上防止在恢复和随后去除海绵时对新形成的组织的损伤。 在实例中，聚合物固有地防止微生物感染并且适合于正常伤口代谢期间所需的氧传递。 喷雾剂包含疏水改性的聚合物，其形成具有血细胞的固体凝胶网络以产生物理凝结机制以防止血液流失。 在一个实例中，喷雾剂还包含至少一种增加凝块的机械完整性的试剂。 在另一个实例中，试剂防止伤口的微生物感染。

公开(公告)号：US08668899B2

公开(公告)日：2014-03-11

申请号：US12946818

申请日：2010-11-15

Applicant: Matthew Dowling ,  Srinivasa Raghavan

Inventor： Matthew Dowling ,  Srinivasa Raghavan

IPC: A61K51/00

CPC classification number: A61M35/003 ,  A61L24/0026 ,  A61L26/0076 ,  A61L2400/04

Abstract: A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. By rapidly expanding upon being released from a canister pressurized with liquefied gas propellant, the foam is able to enter injured body cavities and staunch bleeding. The seal created is strong enough to substantially prevent the loss of blood from these cavities. Hydrophobically-modified polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The amphiphilic polymers form solid gel networks with blood cells to create a physical clotting mechanism that prevent loss of blood.

Abstract translation: 公开了一种用于可压缩和不可压缩（腔内）急性伤口的可喷雾聚合物泡沫止血剂。 泡沫包括疏水改性的聚合物，例如hm-壳聚糖或其它两亲性聚合物，其将自身锚定在伤口附近的细胞膜中。 通过从用液化气推进剂加压的罐中快速膨胀，泡沫能够进入受损的体腔和稳定的出血。 创建的密封件足够强大以防止来自这些空腔的血液的损失。 疏水改性聚合物固有地防止微生物感染，并且适合于正常伤口代谢期间所需的氧传递。 两亲聚合物形成具有血细胞的固体凝胶网络，以产生防止血液丧失的物理凝血机制。

公开(公告)号：US20120058970A1

公开(公告)日：2012-03-08

申请号：US13209399

申请日：2011-08-13

Applicant: Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

Inventor： Matthew Dowling ,  Srinivasa R. Raghavan ,  Rakesh Kumar

IPC: A61K31/722 ,  A61K31/734 ,  A61P7/04 ,  A61K31/717

CPC classification number: A61K31/724 ,  A61L15/28 ,  A61L15/42 ,  A61L26/0023 ,  A61L26/0061 ,  A61L26/0076 ,  A61L2300/232 ,  A61L2400/04

Abstract: A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.

Abstract translation: 疏水改性的生物聚合物与囊泡或细胞膜连接的凝胶化方法。 连接到囊泡或细胞膜上的疏水改性的生物聚合物的凝胶化通过将超分子如环糊精施加到胶凝组合物来逆转。 超分子破坏疏水改性生物聚合物与囊泡或细胞膜之间的相互作用，而不影响疏水性取代基所连接的膜或疏水改性聚合物的结构。 用于治疗包含疏水改性生物聚合物和超分子的伤口的试剂盒。 疏水改性的生物聚合物用于止血，超分子用于除去疏水改性的生物聚合物。