发明授权
US08664253B2 Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents
有权
咪唑衍生物可用作FAAH和FAAH显像剂的调节剂
- 专利标题： Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents
- 专利标题（中）： 咪唑衍生物可用作FAAH和FAAH显像剂的调节剂
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申请号： US13254363申请日： 2010-02-22
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公开(公告)号： US08664253B2公开(公告)日： 2014-03-04
- 发明人: Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G. Hamill , Wenping Li
- 申请人： Ping Liu , Robert J. DeVita , Linus S. Lin , Marc D. Chioda , Terence G. Hamill , Wenping Li
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp
- 当前专利权人： Merck Sharp & Dohme Corp
- 当前专利权人地址： US NJ Rahway
- 代理商 Maria V. Marucci; Valerie J. Camara
- 国际申请： PCT/US2010/024871 WO 20100222
- 国际公布： WO2010/101724 WO 20100910
- 主分类号： A61K31/4178
- IPC分类号： A61K31/4178 ; A61K31/4439 ; C07D401/10
摘要：
The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
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