Several systems and methods for filtering noise from a picture in a picture sequence associated with video data are disclosed. In an embodiment, the method includes accessing a plurality of pixel blocks associated with the picture and filtering noise from at least one pixel block from among the plurality of pixel blocks. The filtering of noise from a pixel block from among the at least one pixel block includes identifying pixel blocks corresponding to the pixel block in one or more reference pictures associated with the picture sequence. Each identified pixel block is associated with a cost value. One or more pixel blocks are selected from among the identified pixel blocks based on associated cost values. Weights are assigned to the selected one or more pixel blocks and set of filtered pixels for the pixel block is generated based on the weights.