A composition includes specific amounts of a poly(phenylene ether), a specific radial block copolymer, a polystyrene-poly(ethylene-butylene)polystyrene triblock copolymer, a specific organophosphate ester, a hydrocarbon resin, and benzoin. The composition exhibits a desirable balance of multiaxial impact strength, light transmittance, and optical clarity, and it can be used to mold a variety of articles including animal cages, ink cartridges, tubes, pipes, and pipe fittings.