发明授权
- 专利标题： Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation
- 专利标题（中）： 将骨髓衍生的多能干细胞募集到外周循环中的药剂
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申请号： US12990047申请日： 2009-04-30
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公开(公告)号： US08673580B2公开(公告)日： 2014-03-18
- 发明人: Katsuto Tamai , Takehiko Yamazaki , Takenao Chino , Yasufumi Kaneda
- 申请人： Katsuto Tamai , Takehiko Yamazaki , Takenao Chino , Yasufumi Kaneda
- 申请人地址： JP Osaka JP Osaka
- 专利权人： Genomix Co., Ltd.,Osaka University
- 当前专利权人： Genomix Co., Ltd.,Osaka University
- 当前专利权人地址： JP Osaka JP Osaka
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 优先权： JP2008-119348 20080430
- 国际申请： PCT/JP2009/058515 WO 20090430
- 国际公布： WO2009/133939 WO 20091105
- 主分类号： G01N33/567
- IPC分类号： G01N33/567
摘要：
The present invention for the first time demonstrated that: (1) bone marrow-derived pluripotent tissue stem cells can be induced in peripheral blood by intravenously administering tissue extract prepared from isolated skin pieces; (2) the substance in the isolated skin pieces, which is responsible for mobilizing bone marrow-derived pluripotent tissue stem cells to peripheral blood, is HMGB1; and (3) HMGB1 with the activity of mobilizing bone marrow-derived pluripotent stem cells to peripheral blood can be easily purified from cultured cells.
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