Invention Grant
- Patent Title: High-yield method for the production of human antibodies blocking the biological activity of a human cytokine
- Patent Title (中): 用于生产阻断人细胞因子生物活性的人抗体的高产率方法
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Application No.: US10572361Application Date: 2004-09-15
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Publication No.: US08679483B2Publication Date: 2014-03-25
- Inventor: Bernard Bizzini , Helene Le Buanec , Daniel Zagury
- Applicant: Bernard Bizzini , Helene Le Buanec , Daniel Zagury
- Applicant Address: FR Paris
- Assignee: Neovacs
- Current Assignee: Neovacs
- Current Assignee Address: FR Paris
- Agency: Browdy and Neimark, PLLC
- Priority: FR0350543 20030916
- International Application: PCT/FR2004/050436 WO 20040915
- International Announcement: WO2005/028513 WO 20050331
- Main IPC: C07K16/06
- IPC: C07K16/06 ; C07K16/24
Abstract:
The invention concerns a pharmaceutical composition comprising, as the active ingredient, human natural antibodies of the IgG isotype, that neutralize the activity of a human cytokine selected from VEGF, IFNα, IL-4, TNFα and TGFβ, the said neutralizing antibodies inhibiting at least 50% of the maximum biological activity induced by an amount ranging from 0.006 ng to 0.05 ng of the said cytokine in vitro.
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