发明授权
US08680098B2 Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
有权
用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
- 专利标题： Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
- 专利标题（中）： 用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
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申请号： US13034922申请日： 2011-02-25
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公开(公告)号： US08680098B2公开(公告)日： 2014-03-25
- 发明人: Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
- 申请人： Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
- 申请人地址： BE
- 专利权人： Janssen Pharmaceutica, NV
- 当前专利权人： Janssen Pharmaceutica, NV
- 当前专利权人地址： BE
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/5377 ; A61K31/437 ; A61K31/52 ; A61K31/4985 ; A61P29/00 ; C07D487/04
摘要：
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
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