Invention Grant
US08680098B2 Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
有权
用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
- Patent Title: Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
- Patent Title (中): 用作TRPM8受体调节剂的取代的氮杂 - 双环咪唑衍生物
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Application No.: US13034922Application Date: 2011-02-25
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Publication No.: US08680098B2Publication Date: 2014-03-25
- Inventor: Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
- Applicant: Mark R. Player , Raul Calvo , Jinsheng Chen , Sanath Meegalla , Daniel Parks , William Parsons , Scott Ballentine , Shawn Branum
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica, NV
- Current Assignee: Janssen Pharmaceutica, NV
- Current Assignee Address: BE
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/5377 ; A61K31/437 ; A61K31/52 ; A61K31/4985 ; A61P29/00 ; C07D487/04
Abstract:
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
Public/Granted literature
- US20110218197A1 SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS Public/Granted day:2011-09-08
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