Invention Grant
- Patent Title: Regulation of macrophage activation using miR-125b
- Patent Title (中): 使用miR-125b调节巨噬细胞活化
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Application No.: US13526347Application Date: 2012-06-18
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Publication No.: US08685727B2Publication Date: 2014-04-01
- Inventor: Aadel Chaudhuri , Alex Steven So , David Baltimore , Ryan M. O'Connell
- Applicant: Aadel Chaudhuri , Alex Steven So , David Baltimore , Ryan M. O'Connell
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Knobbe, Martens, Olson & Bear LLP
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C07H21/02 ; C07H21/04
Abstract:
The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.
Public/Granted literature
- US20120322854A1 REGULATION OF MACROPHAGE ACTIVATION USING MIR-125B Public/Granted day:2012-12-20
Information query
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