发明授权
- 专利标题: Multispecific peptides
- 专利标题(中): 多特异性肽
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申请号: US13147289申请日: 2010-02-04
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公开(公告)号: US08685890B2公开(公告)日: 2014-04-01
- 发明人: Gregory Paul Winter , Christian Heinis , Elise Bernard , David Loakes , John Tite , Marina Vaysburd , Daniel Paul Teufel , Lutz Riechmann
- 申请人: Gregory Paul Winter , Christian Heinis , Elise Bernard , David Loakes , John Tite , Marina Vaysburd , Daniel Paul Teufel , Lutz Riechmann
- 申请人地址: GB Cambridge
- 专利权人: Bicycle Therapeutics Limited
- 当前专利权人: Bicycle Therapeutics Limited
- 当前专利权人地址: GB Cambridge
- 代理机构: Convergent Law Group LLP
- 优先权: WOPCT/GB2009/000301 20090204; GB0913775.3 20090806
- 国际申请: PCT/EP2010/000689 WO 20100204
- 国际公布: WO2010/089115 WO 20100812
- 主分类号: C40B30/04
- IPC分类号: C40B30/04
摘要:
The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.
公开/授权文献
- US20120101256A1 MULTISPECIFIC PEPTIDES 公开/授权日:2012-04-26
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