发明授权
US08685996B2 Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
有权
制备3-O-保护的吗啡酮和3-O-保护的吗啡酮二烯酚羧酸酯的方法
- 专利标题： Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
- 专利标题（中）： 制备3-O-保护的吗啡酮和3-O-保护的吗啡酮二烯酚羧酸酯的方法
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申请号： US13472227申请日： 2012-05-15
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公开(公告)号： US08685996B2公开(公告)日： 2014-04-01
- 发明人: Andreas Stumpf
- 申请人： Andreas Stumpf
- 申请人地址： US CT Stamford
- 专利权人： Purdue Pharma L.P.
- 当前专利权人： Purdue Pharma L.P.
- 当前专利权人地址： US CT Stamford
- 代理机构： Dechert LLP
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; C07D489/02
摘要：
Disclosed are methods for making aldehydes and ketones comprising allowing the corresponding primary or secondary alcohol to react in the presence of trichoroisocyanuric acid, a compound of formula R1SR2 and a base. In one embodiment, the alcohol is a compound of formula (I): wherein R3 is a protecting group. Also disclosed are methods for making 3-O-protected morphine dienol carboxylates comprising allowing a compound of formula (I) to oxidize in the presence of a chlorine-containing compound and a compound of formula R1SR2; and allowing the product of the oxidation step to react with an acylating agent.
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