Invention Grant
- Patent Title: Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
- Patent Title (中): 11-和β-羟基类固醇脱氢酶1型抑制剂
-
Application No.: US13233699Application Date: 2011-09-15
-
Publication No.: US08686011B2Publication Date: 2014-04-01
- Inventor: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- Applicant: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric A. Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- Applicant Address: US CA Thousand Oaks SE Stockholm
- Assignee: Amgen Inc.,Biovitrum AB
- Current Assignee: Amgen Inc.,Biovitrum AB
- Current Assignee Address: US CA Thousand Oaks SE Stockholm
- Agency: Foley & Lardner LLP
- Priority: SE0401324 20040524; SE0402509 20041015
- Main IPC: A61K31/427
- IPC: A61K31/427 ; C07D277/34 ; C07D277/38 ; C07D277/42
Abstract:
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Public/Granted literature
- US20120010256A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 Public/Granted day:2012-01-12
Information query
IPC分类:
