Invention Grant
- Patent Title: Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
- Patent Title (中): 利用合成气或其他气态碳源和甲醇的方法和生物
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Application No.: US12863978Application Date: 2009-01-22
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Publication No.: US08691553B2Publication Date: 2014-04-08
- Inventor: Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
- Applicant: Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Jones Day
- International Application: PCT/US2009/031737 WO 20090122
- International Announcement: WO2009/094485 WO 20090730
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N9/00 ; C12N1/00 ; C12P7/42 ; C12P7/20 ; C07H21/04

Abstract:
The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
Public/Granted literature
- US20110195461A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL Public/Granted day:2011-08-11
Information query
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